Skp2B overexpression alters a prohibitin-p53 axis and the transcription of PAPP-A, the protease of insulin-like growth factor binding protein 4.
We previously reported that the degradation of prohibitin by the SCF(Skp2B) ubiquitin ligase results in a defect in the activity of p53.We also reported that MMTV-Skp2B transgenic mice develop mammary gland Suspension Shock Absorber Wrench tumors that are characterized by an increased proteolytic cleavage of the insulin-like growth factor binding p